Final answer:
The response is called b. endocrine signaling, which involves the release of hormones into the bloodstream to affect distant cells.
Step-by-step explanation:
When a cell makes a cytokine that affects a distant cell, the response is called endocrine signaling. b. Endocrine signaling involves the release of hormones into the bloodstream, allowing them to travel to distant target cells to elicit a response.
Unlike paracrine signaling, which acts on nearby cells, endocrine signaling is long-range and can have widespread effects throughout the body.