Question

The condition X-linked severe combined immunodeficiency (X-SCID) is due to a mutation in the gene coding for a subunit of:

A. the IL-2 receptor.
B. IL-2.
C. the T-cell receptor.
D. MHC class I.

Answer 1

X-linked severe combined immunodeficiency (X-SCID) is typically caused by a mutation in the gene for a subunit of the IL-2 receptor, leading to compromised immune system responses and higher susceptibility to infections.

Step-by-step explanation:

The X-linked severe combined immunodeficiency (X-SCID) is a condition stemming from a genetic mutation that impairs the immune system by affecting both T-cell and B-cell responses. This particular form of SCID is most often due to a mutation in the gene coding for a subunit of the IL-2 receptor (A).

This mutation disrupts normal signaling that is important for the growth and differentiation of T cells and B cells, leading to the severe immunodeficiency observed in X-SCID patients. As such, these individuals are highly susceptible to opportunistic infections and require treatments such as bone marrow transplants or gene therapy in some cases.

Answer 2

X-linked severe combined immunodeficiency (X-SCID) is caused by a mutation in the gene encoding for a subunit of the IL-2 receptor, leading to defective immune system responses. A is the correct answer.

Step-by-step explanation:

The condition X-linked severe combined immunodeficiency (X-SCID) is due to a mutation in the gene coding for a subunit of the IL-2 receptor.

X-SCID is a genetic disorder that impairs the function of certain white blood cells essential to the immune system, specifically affecting both the B cell and T cell arms of the adaptive immune response.

This condition is most often caused by an X-linked recessive mutation, which severely affects T-cell dependent antibody responses and cell-mediated immune responses, making individuals with X-SCID highly susceptible to a range of opportunistic infections.