Question

Which of the following is a protein tyrosine kinase involved in T-cell activation culminating in T-cell proliferation and differentiation?

a. AP-1
b. ZAP-70
c. NFκB
d. NFAT
e. calcineurin.

Answer 1

ZAP-70 is the protein tyrosine kinase involved in T-cell activation that leads to T-cell proliferation and differentiation. It plays a critical role in the signaling sequences following antigen recognition on T-cells.

Step-by-step explanation:

The protein tyrosine kinase involved in T-cell activation culminating in T-cell proliferation and differentiation is ZAP-70.

When T cells recognize antigens, the T-cell receptor (TCR) is activated and recruits ZAP-70, which then gets phosphorylated and activated.

The active ZAP-70 kinase initiates a series of phosphorylation cascades that eventually lead to T-cell proliferation and differentiation.

Activation of ZAP-70 is a crucial step for the downstream signaling pathways, including the MAP-kinase cascade, which is involved in cellular metabolism and cell division.

It is important to note that NFκB and calcineurin also play roles in T-cell activation but through different mechanisms.

NFκB is involved in the transcription of genes related to inflammatory responses and survival, while calcineurin dephosphorylates NFAT, an important transcription factor in T-cells.