Final answer:
T-cells enter the lymph node through afferent lymphatic vessels and gather in the lymphoid follicles. Antigens are presented to T-cells by Antigen-Presenting Cells in the lymph nodes, which activates the T-cells. The lymph then exits the lymph node via efferent lymphatic vessels.
Step-by-step explanation:
T-cells enter a lymph node via the afferent lymphatic vessels. Once inside, the lymph containing cells and antigens flows into the subcapsular sinus, which houses dendritic cells, macrophages, and reticular fibers. The lymphoid follicles in the cortex are vital areas where T-cells gather, forming a protective layer around rapidly dividing B cells.
Antigen presentation occurs when antigens gathered by the lymph are processed and presented by Antigen-Presenting Cells (APCs) to T-cells. APCs in the lymph nodes capture and process antigens, initiating the activation of T-cells. After their activation, T-cells participate in the adaptive immune response to fight off infections.
Additional migration occurs as lymph and lymphocytes exit the lymph node through efferent lymphatic vessels, continuing their role in immune surveillance throughout the body. This process is a critical part of the body's immune defense, preparing T-cells to encounter and respond to pathogens effectively.