Final answer:
During Michael Cerularius' reign, desecration of holy icons and vessels occurred, contributing to the East-West Schism and angering Cardinal Humbert.
Step-by-step explanation:
The great desecration during the reign of Michael Cerularius that angered the Latin Cardinal Humbert is related to the events leading up to the East-West Schism, also known as the Great Schism of 1054. This historical incident involved temples being desecrated, where sacred objects were disrespectfully mishandled, and holy icons and holy vessels were desecrated. The conflict was not only about religious artifacts but also encompassed deep-rooted theological and political disagreements between the Eastern (Orthodox) and Western (Roman Catholic) Christian traditions.