Final answer:
The statement is true as in many CAD software applications, the first selection with the Measure command sets the reference for all subsequent measurements until cleared.
Step-by-step explanation:
The statement that in the Measure command, the first selection made will always be used as the reference for the measurement until the selection is cleared is true. This is a common behavior in various computer-aided design (CAD) software applications, where the measure tool requires a reference point or object from which all subsequent measurements are made. Once the first selection is made, the measurements are referenced from this point until the user clears the selection or exits the measurement command.