Question

Which of these mutations do you predict would most likely b dominant to a wild type allele in producing a mutant phenotype?

a) dominant negative
b) hypomorphic
c) null
d) none of the above

Answer 1

A dominant negative mutation is most likely to be dominant to a wild type allele in producing a mutant phenotype.

Step-by-step explanation:

The mutation that would most likely be dominant to a wild type allele in producing a mutant phenotype is a dominant negative mutation. A dominant negative mutation occurs when the gene product adversely affects the normal, wild-type gene product within the same cell. This happens when the mutant protein can still interact with the same elements as the wild-type protein, but it blocks or inhibits some aspect of its function. Dominant negative mutations are often gain-of-function mutations.