Final answer:
The rearrangement of VH to DJH in B cell maturation induces transcription of the DJH promoter, confirming the statement as true. This process involves enhancers and transcription factors that drive the increased transcription of specific gene segments to produce diverse antibodies.
Step-by-step explanation:
Rearrangement of VH to DJH on the immunoglobulin heavy chain locus is an essential process in the maturation of B cells, which ultimately leads to the production of antibodies. This genetic rearrangement induces transcription of the DJH promoter, resulting in a true statement regarding B cell maturation. It is also notable that mutations in promoters can alter the binding site for transcription factors, leading to changes in the rate of transcription; however, it is context-dependent whether a mutated promoter will increase or decrease transcription or possibly even halt it altogether.
The process of B cell maturation involves an enzyme called DNA recombinase, which randomly excises V (variable) and D (diversity) and J (joining) segments from the immunoglobulin gene. During this process, transcription factors bind to enhancer regions to initiate the recruitment of RNA polymerase, which substantially increases transcription of the rearranged gene segment.
It is important to distinguish this legitimate biological mechanism from incorrect statements, such as the false notion that reverse transcriptase translates RNA into protein, as reverse transcriptase actually converts RNA back into DNA in retroviruses like HIV.