Question

Pro-B cells express a surrogate light chain (SLC) that consists of (2). What does this surrogate light chain combine with to form the PRE-B cell receptor?

a) VpreB and Lambda 5; Heavy chain
b) VpreB and Lambda 5; Surrogate heavy chain
c) VpreA and Lambda 6; Light chain
d) VpreA and Lambda 6; Heavy chain

Answer 1

The surrogate light chain expressed by Pro-B cells combines with VpreB and Lambda 5; Heavy chain to form the PRE-B cell receptor, which is essential in the maturation process of the B cell.

Step-by-step explanation:

The surrogate light chain (SLC) expressed by Pro-B cells combines with a heavy chain to form the PRE-B cell receptor. The correct combination for SLC is VpreB and Lambda 5; this forms part of the pre-B cell receptor complex, which is involved in the early stages of B cell development. Upon successful heavy chain rearrangement, the expression of the pre-B cell receptor signals the pro-B cell to become a pre-B cell and stop rearranging the heavy chain gene. This receptor also signals the cell to begin rearranging the light chain gene, which will eventually replace the surrogate light chain, to form a fully functional B cell receptor capable of binding to an antigen.