Question

How many CDRs are there in the heavy chain V region?

a) 1
b) 2
c) 3
d) 4

Answer 1

The heavy chain V region of an immunoglobulin contains three complementarity determining regions (CDRs), which are crucial for antigen recognition and binding.

Step-by-step explanation:

The heavy chain V region of an immunoglobulin contains three complementarity determining regions (CDRs). These regions are important for antigen recognition and binding. The CDRs in the heavy chain are held in place by the more conserved framework regions, creating a surface that is complementary to the surface of a bound antigen. In a heavy chain, these hypervariable or CDRs are located at specific amino acid positions, which correspond to the following sequences: 31 through 37, 51 through 68, 86 through 91, and 101 through 109. Therefore, there are three CDRs in the heavy chain V region of an immunoglobulin.