Final answer:
Naive T cell entry into the lymph node includes the stages of rolling, adhesion, diapedesis, and transmigration, which allow T cells to efficiently locate target antigens within the lymph node.
Step-by-step explanation:
The naive T cell entry into the lymph node (LN) generally involves a sequence of events which ensure that the T cells can efficiently find their target antigen within the lymph nodes. These stages of entry are the following: rolling, adhesion, diapedesis, and transmigration. Initially, rolling occurs when T cells loosely bind to the endothelium through selectins, slowing down their movement through the bloodstream. Next, the adhesion stage is marked by firmer binding via integrins to the endothelial cells. Following that, diapedesis takes place where the T cells squeeze between the endothelial cells, passing through the blood vessel wall. Lastly, during transmigration, T cells move out of the vasculature into the lymph node tissue.