Question

Which 2 chemokines stimulate naive T cell diapedesis?

a) CXCL12 and CCL21
b) IL-2 and IL-4
c) IFN-γ and TNF-α
d) TGF-β and IL-10

Answer 1

The two chemokines that stimulate naive T cell diapedesis are CXCL12 and CCL21, essential for guiding T cell movement into tissues during an immune response.

Step-by-step explanation:

The 2 chemokines that stimulate naive T cell diapedesis are a) CXCL12 and CCL21. Cytokines and chemokines play crucial roles in the immune response, with chemokines being responsible for chemotaxis or the attraction of cells from longer distances. In the context of T cells, chemokines are involved in guiding the migration of naive T cells to the appropriate location during an immune response. Chemokines like CXCL12 and CCL21 are especially important for enabling naive T cells to leave the bloodstream and enter the tissues where they can then engage with antigen-presenting cells (APCs) to become activated and differentiate into either helper T cells or cytotoxic T cells, depending on whether they are CD4+ or CD8+ T cells, respectively.