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What molecule do naive T lymphocytes express that allows the rolling stage of LN entry?

a) ICAM-1
b) VCAM-1
c) L-selectin
d) Integrin

1 Answer

4 votes

Final answer:

Naive T lymphocytes express L-selectin for the rolling stage of lymph node entry. Helper T cells bind antigens presented with MHC II molecules, and cytotoxic T lymphocytes bind MHC I molecules on APCs via CD8 co-receptors for viral infection response, alongside natural killer cells.

Step-by-step explanation:

Naive T lymphocytes express L-selectin which allows them to roll along the endothelial cells of the blood vessel as they approach the entry point into a lymph node. This molecule enables the initial weak adhesion required for their movement toward the lymph node through the blood vessels. Upon encountering an antigen-presenting cell, naïve T cells can become activated. The TCR (T-cell receptor) of helper T cells binds to antigens presented with MHC II molecules. Cytotoxic T lymphocytes (CTLs) bind MHC molecules on APCs via the CD8 co-receptors on their cell surfaces, allowing them to identify virally infected cells. All nucleated cells present MHC I molecules, which can activate T cells when foreign antigens are associated with them. Finally, the type of immune response that works in concert with cytotoxic T cells against virally infected cells is that of natural killer cells.

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