Final answer:
IL-1Beta, IL-6, and TNF-alpha are the 3 cytokines that cause the acute-phase response.
Step-by-step explanation:
The cytokines that cause the acute-phase response are IL-1Beta, IL-6, and TNF-alpha. These cytokines play critical roles in the body's inflammatory response. They trigger the production of acute-phase proteins and other mediators that contribute to local and systemic inflammation. Specifically, IL-1Beta induces vasodilation and reduces the tight junctions between vascular endothelial cells, leading to edema. IL-6 is a central player in the acute-phase response, supporting the differentiation of B cells, among other roles. TNF-alpha helps regulate immune cells and can induce fever, apoptotic cell death, inflammation, and inhibit tumorigenesis. Collectively, these cytokines orchestrate a complex network of immune responses to defend against infections and other threats.