Final answer:
TLR4 does not exclusively use MyD88 as its adaptor; it can also use the TRIF adaptor protein, making the statement false.
Step-by-step explanation:
The statement that TLR4 can exclusively use MyD88 as its adaptor is false. TLR4 is known to use both MyD88-dependent and MyD88-independent pathways for signalling. Specifically, in addition to MyD88, TLR4 can also signal via the TRIF adaptor protein, which activates a distinct set of downstream responses. Therefore, TLR4 does not exclusively rely on MyD88. MyD88 is involved in the early signalling at the plasma membrane, while TRIF is involved in the late signalling at the endosomes.