Final answer:
Polar and charged amino acids are more likely to be found on the surface of a soluble protein, while non-polar amino acids are found in the interior.
Step-by-step explanation:
Amino acids can be categorized as polar/charged and non-polar. In soluble proteins, polar and charged amino acids are most likely to be found on the surface, while non-polar amino acids are found in the interior. The hydrophilic R groups of the polar/charged amino acids face outwards, while the non-polar amino acids are held in the interior by hydrophobic interactions.