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Indicate how each of the following components are involved in endocytosis. Which one is key in the initiation of transmitter release by Ca2+?

a. Adaptor proteins
b. Clathrin triskelia
c. Dynamin ring
d. Actin
e. Hsc-70
f. Auxilin

1 Answer

2 votes

Final answer:

In endocytosis, adaptor proteins, clathrin, dynamin, actin, Hsc-70, and auxilin are involved in various stages such as vesicle formation, pinch-off, and uncoating. Ca2+ is crucial for triggering exocytosis, not endocytosis.

Step-by-step explanation:

The components involved in endocytosis each play unique roles in the process of internalizing substances into a cell:

  • Adaptor proteins - They connect clathrin to the receptors on the cell membrane and help in cargo selection.
  • Clathrin triskelia - Clathrin is the principal protein forming the structure of coated pits and vesicles in the cell membrane during endocytosis.
  • Dynamin ring - Dynamin assists in the 'pinch-off' of the vesicle from the plasma membrane through GTP hydrolysis.
  • Actin - It may be involved in providing mechanical force during the formation of vesicles.
  • Hsc-70 - It's involved in the uncoating of clathrin-coated vesicles after endocytosis.
  • Auxilin - It recruits Hsc-70 to clathrin vesicles to assist in uncoating.

Out of these components, Ca2+ is key in the initiation of neurotransmitter release during exocytosis, not endocytosis. It triggers the vesicles to fuse with the plasma membrane and release their contents out of the cell.

User Manish Das
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