Final answer:
Chromosome segregation during cell division depends on the presence of a centromere. Without a centromere, proper segregation may not occur. If there are multiple centromeres on a chromosome, it can lead to errors in segregation.
Step-by-step explanation:
In normal cell division, chromosome segregation occurs during anaphase, where the sister chromatids separate and move to opposite ends of the cell. The centromere plays a crucial role in ensuring proper chromosome segregation. If a chromosome does not have a centromere, it will not be able to attach to the spindle fibers and segregate properly, potentially leading to errors in cell division. On the other hand, if there are two centromeres in different locations on the same chromosome, it can result in unequal segregation of genetic material and consequently, abnormal cell division.