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How does base excision DNA repair work?

User Jaege
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Final answer:

Base excision DNA repair is a mechanism that corrects damage to a single nucleotide. It involves the removal of the damaged base and its replacement with the correct base.

Step-by-step explanation:

Base excision DNA repair is a type of DNA repair mechanism that corrects damage to a single nucleotide caused by oxidation, alkylation, hydrolysis, or deamination. This repair mechanism involves the removal of the damaged base by a specific enzyme called glycosylase. Once the damaged base is removed, it is replaced with the correct base through repair synthesis with DNA polymerase, and the gap is sealed with a phosphodiester linkage catalyzed by DNA ligase.

User Sareuon
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