Final answer:
The query concerns the type of antibodies associated with extragenital lichen sclerosis and a gene mutation in another condition, which is identified as IgG antibodies related to Pemphigus vulgaris.
Step-by-step explanation:
The question resembles a query about the association of antibodies with certain skin conditions and asks for the identification of a gene mutation that is present in another condition. Specifically, the discussion revolves around extragenital lichen sclerosis and the antibodies involved. The correct answer to this question is IgG; Pemphigus vulgaris, where IgG is the type of antibody involved, and Pemphigus vulgaris is a condition with a mutation in a gene that affects the skin, characterized by autoantibodies attacking the desmosomes in skin cells.
Pemphigus vulgaris is an autoimmune disorder where IgG antibodies target proteins in the desmosomes that are essential for cell adhesion in the epidermis. This results in the blistering and erosion of the skin and mucous membranes. In contrast, lichen sclerosis involves a different pathogenesis and is not typically associated with the same antibodies or gene mutations seen in Pemphigus vulgaris.