Question

For the purposes of this course, what change occurs at the synapse during LTP (Long-Term Potentiation)?

a) Decrease in neurotransmitter release
b) Increase in synaptic strength
c) Reduction in dendritic connections
d) Inhibition of postsynaptic receptors

Answer 1

For the purposes of the course, the change that occurs at the synapse during Long-Term Potentiation (LTP) is an increase in synaptic strength due to the addition of AMPA receptors to the postsynaptic membrane.

Step-by-step explanation:

During Long-Term Potentiation (LTP), a change that occurs at the synapse is an increase in synaptic strength. This increase in synaptic strength is due to the addition of AMPA receptors to the postsynaptic membrane, resulting from a cascade initiated by Ca²⁺ ions entering through NMDA receptors. The added AMPA receptors enhance the postsynaptic cell's response to future releases of glutamate from the presynaptic cell. In contrast, Long-Term Depression (LTD) represents the weakening of synaptic connections, where AMPA receptors are removed from the postsynaptic membrane, making it less responsive to glutamate.