Final answer:
Heat can enable the hybridization of two single strands of DNA by causing the denaturation of the double helix, which separates the strands and allows them to reanneal upon cooling if they are complementary.
Step-by-step explanation:
The process that can enable the hybridization of two single strands of DNA is by applying heat. When DNA is exposed to high temperatures, it undergoes a process known as denaturation, where the hydrogen bonds between the complementary nitrogenous bases are disrupted. This results in the separation of the double-stranded DNA into two single strands. Upon cooling, these ssDNA strands can reanneal, meaning that they can re-form hydrogen bonds and return to their double-stranded form if their sequences are complementary. This property of DNA is crucial for many biotechnological applications, including DNA replication and polymerase chain reaction (PCR).