Final answer:
You should not handle a hamster when it is sleeping. Wait for the hamster to wake naturally and avoid disturbing it while running in its wheel or eating. Handling a hamster while it sleeps can cause stress and lead to defensive behavior.
Step-by-step explanation:
It is generally not recommended to handle a hamster when it is sleeping. Hamsters are nocturnal animals, meaning they sleep during the day and are active at night. Disturbing a hamster while it sleeps can stress the animal and may result in defensive biting. You should allow them to wake naturally and adjust to their surroundings before attempting to handle them. When they are awake, ensure that they are not running in their wheel or actively eating, as these activities are important for their well-being and interrupting them might cause unnecessary stress or fear.