Question

In the category page of LINCC Electronic Resources, find the database as

indicated in the listing below, and find the article:
Feng, L. R., and K. A. Maguire-Zeiss. "Gene Therapy in Parkinson's Disease:
Rationale and Current Status." CNS Drugs 24.3 (2010): 177-92. Medline with Full
Text. Web. 9 Sept. 2010.
Which of the following is the frst sentence in the article and the abstract?
a. Parkinson's disease is typified by the progressive loss of substantia nigra pars
compacta dopamine neurons and the consequent decrease in the neurotransmitter
dopamine.
b. Typified by the progressive loss of substantia nigra pars compacta dopamine neurons
and the consequent decrease in the neurotransmitter dopamine.
c. Parkinson's disease is the second most common age-related neurodegenerative
disorder.
d. Parkinson's disease is the second most common age-related neurodegenerative
disorder, typifed by the progressive loss of substantia nigra pars compacta dopamine
neurons and the consequent decrease in the neurotransmitter dopamine.

Answer 1

The first sentence in the specified article is "Parkinson's disease is the second most common age-related neurodegenerative disorder, typified by the progressive loss of substantia nigra pars compacta dopamine neurons and the consequent decrease in the neurotransmitter dopamine."

Step-by-step explanation:

The abstract of Feng, L. R., and K. A. Maguire-Zeiss. "Gene Therapy in Parkinson's Disease: Rationale and Current Status." is d. Parkinson's disease is the second most common age-related neurodegenerative disorder, typified by the progressive loss of substantia nigra pars compacta dopamine neurons and the consequent decrease in the neurotransmitter dopamine.

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons within the substantia nigra pars compacta (SNc) leading to motor symptoms such as tremors and rigidity. These neurons are essential in the modulation of movement via the neurotransmitter dopamine. As the disease progresses, treatments like L-DOPA are used to increase dopamine levels and alleviate symptoms, although there is no cure for PD. Additionally, cognitive and psychological symptoms such as dementia or depression are prevalent as PD advances.