Final answer:
Integral membrane proteins are embedded within the plasma membrane and have important functions. They require specific conditions to be removed, such as the disruption of the membrane by detergents.
Step-by-step explanation:
Integral membrane proteins are proteins that are embedded within the plasma membrane and have important functions such as channeling or transporting molecules across the membrane. These proteins require specific conditions to be removed, such as the disruption of the membrane by detergents. For example, the presence of hydrophobic alpha-helical domains in transmembrane proteins makes them difficult to isolate from membranes in a biologically active form.