Final answer:
The orientation of a region of the cell facing the extracellular side can be determined by understanding the structure of the cell membrane. The extracellular side refers to the side of the cell membrane that faces the exterior environment, while the intracellular side faces the interior of the cell.
Step-by-step explanation:
The orientation of a region of the cell facing the extracellular side can be determined by understanding the structure of the cell membrane. The cell membrane consists of a phospholipid bilayer, with the hydrophobic lipid tails facing inward and the hydrophilic phosphate groups facing outward. The extracellular side refers to the side of the cell membrane that faces the exterior environment, while the intracellular side faces the interior of the cell.