Final answer:
Keratinocytes in the Stratum Basale do have a nucleus and organelles when they are first formed and only lose them when they reach the stratum corneum.
Step-by-step explanation:
False. Keratinocytes in the Stratum Basale do have a nucleus and organelles when they are first formed. The stratum basale, also known as the basal layer, is the deepest layer of the epidermis, separated from the dermis by a basement membrane. This layer is primarily made up of basal cells, which are stem cells responsible for producing new keratinocytes. These basal cells divide and the newly formed keratinocytes then get pushed upward, starting their journey through the different layers of the epidermis. As these cells migrate towards the surface, they start to differentiate and accumulate keratin, a protective protein. It is only in the uppermost layer, the stratum corneum, that the keratinocytes lose their nucleus and organelles, becoming dead, flat, and filled with keratin.