Final answer:
While the provided references do not directly discuss the Suga lab illustration of flexizyme, they do explore the concept of flexibility in enzymatic recognition through fleximers, which may operate under similar principles to flexizymes by enhancing enzyme binding and potential therapeutic application.
Step-by-step explanation:
The Suga lab illustration of flexizyme is not directly mentioned in the provided literature; however, the concept of flexizyme may refer to the utilization of flexible nucleotide analogs in enzymatic processes. Suga's lab has worked extensively on creating flexizymes, which are synthetic ribozymes that can incorporate non-standard amino acids into peptides.
The parallel here is the investigation into the flexibility of nucleosides and their impact on enzyme function, as mentioned in the Seley-Radtke group's research, where they studied the effects of flexible nucleoside analogs, known as fleximers, on enzyme recognition and activity.
Their work showed that splitting the purine base into its imidazole and pyrimidine components, allowing for free rotation, can lead to enhanced enzyme binding and the potential for overcoming mutations in enzyme binding sites as well as exploring possible therapeutic uses.