Question

Describe the structure and function of G-protein coupled receptors and their importance as targets for drug discovery.

a) G-protein coupled receptors are primarily found in the nucleus.
b) G-protein coupled receptors function by directly binding to DNA.
c) G-protein coupled receptors play a role in signal transduction.
d) G-protein coupled receptors are not significant in drug discovery.

Answer 1

G-protein coupled receptors (GPCRs) are integral membrane proteins that function by binding to a ligand and activating an associated G-protein. They play a crucial role in signal transduction and are important targets for drug discovery, as they are involved in many physiological processes and serve as the target of about 30% of modern drugs.

Step-by-step explanation:

G-protein coupled receptors (GPCRs) are integral membrane proteins that play a crucial role in signal transduction. They are not primarily found in the nucleus, but rather in the cell membrane. GPCRs function by binding to a ligand, which leads to the activation of an associated G-protein. The activated G-protein then interacts with other proteins in the cell, such as ion channels or enzymes, to initiate a cellular response.

GPCRs are of great importance as targets for drug discovery. They are involved in a wide range of physiological processes and are the target of about 30% of all modern drugs. By modulating the activity of GPCRs, drugs can influence various cellular pathways and treat a variety of diseases.