Final answer:
Cells will lose water and shrink when placed in a hypertonic solution that contains a solute impermeable to the cell membrane.
Step-by-step explanation:
In a hypertonic solution, if cells are placed in a solute to which the membrane is impermeable, the cells will lose water and shrink. This happens because the hypertonic solution outside the cell has a higher concentration of solutes than the cell's cytoplasm, causing water to leave the cell through osmosis. As a result, the cells will shrink and may even die.