Final answer:
The question touches on historical public health and social reform efforts in South Carolina, referencing events such as the Nullification Crisis and the controversial sterilization policy, as well as nineteenth-century reforms in public institutions.
Step-by-step explanation:
The question refers to a period in South Carolina's history when the state was dealing with significant public health and social issues. This includes times when the state was experiencing challenges such as civil unrest, public health campaigns, and social reform activities. For instance, during the Nullification Crisis in the late 1820s and early 1830s, South Carolina threatened to secede from the Union over tariffs, leading to President Andrew Jackson sending federal troops and Congress passing the Force Bill.
Additionally, the state has been involved in controversial public health policies, such as the nearly five hundred sterilizations that took place in one county between 1946 and 1968. Lastly, the reform of prisons, asylums, and schools in the nineteenth century is another point of reference, marking a shift toward handling social issues through public institutions instead of family and voluntary efforts.