Final answer:
The integration center of a reflex arc is not always located in the CNS. Some reflex arcs can be monosynaptic and do not involve interneurons or the CNS.
Step-by-step explanation:
The integration center of a reflex arc is not always located in the CNS. While it is true that some reflex arcs involve multiple synapses with chains of interneurons in the CNS, there are cases where the center may be a single synapse between a motor and a sensory neuron. This is known as a monosynaptic reflex arc. Monosynaptic reflex arcs do not involve interneurons or the CNS, and instead have a direct connection between the sensory and motor neurons.