Final answer:
Upon returning from Duncan's chamber, Macbeth is overwhelmed with guilt and horror at his actions. He struggles with the blood on his hands and cannot bring himself to return the daggers, prompting Lady Macbeth to take over.
Step-by-step explanation:
Macbeth's reaction upon returning from Duncan's chamber was one of horror and guilt. After murdering King Duncan, Macbeth is distraught, and this is reflected when he talks to Lady Macbeth.
He is clearly disturbed by what he has done and shows signs of immediate regret and fear of the consequences.
His hands are covered in blood, and he is so shaken that he brings the murder weapons, the daggers, with him rather than leaving them with the sleeping guards as per the plan devised by Lady Macbeth, who sees it necessary to take charge of the situation.
She instructs him to wash the blood from his hands and scolds him for his inability to return the daggers, which she then does herself.
Macbeth, on the other hand, is overwhelmed by the gravity of his actions and states that not all the water in the ocean could clean his hands of the blood.