Final answer:
Pablo Neruda's most famous work is 'Twenty Love Poems and a Song of Despair', a collection that explores themes of love and loss with profound imagery and emotion.
Step-by-step explanation:
One of Pablo Neruda's most famous poems is Twenty Love Poems and a Song of Despair. This collection of poems has made a significant impact since its publication and is revered in the literary community. It is known for its vivid imagery, emotional depth, and the way it delves into themes of love and loss.