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Are there any examples of two visible or obvious phenotypic traits in humans that are a priori unrelated, but which tend to be inherited together (i.e. their inheritance probabilities are correlated) due to genetic linkage from their proximity on a chromosome?

I know that peas' flower color and grain shape are genetically linked, but are there any similar examples in humans?

User Arvid
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Final answer:

Genetic linkage in humans can result in the correlated inheritance of certain traits, such as hair color and eye color. Linkage maps help determine gene positions on chromosomes, with recombination leading to genetic diversity. Polygenic traits like skin color and height involve multiple genes and show polygenic inheritance.

Step-by-step explanation:

Genetic linkage occurs when genes are located in close proximity on the same chromosome, leading to a higher probability of certain traits being inherited together. An example in humans is the linkage between hair color and eye color, where genes dictating these traits tend to be inherited together, like the combination of blonde hair with blue eyes and brown hair with brown eyes. This concept is vital in understanding how certain human traits, which may appear unrelated, are often inherited in a correlated fashion.

Beyond hair and eye color, other human traits such as certain diseases can also be inherited together due to linkage. For example, the BRCA1 and BRCA2 genes, which are linked to breast cancer, are located on chromosomes 17 and 13, respectively.

Genetic recombination during sexual reproduction can occasionally break the link between genes, especially when they are further apart on the chromosome. This recombination leads to genetic diversity and is an essential aspect of sexual reproduction. As genes get farther apart on a chromosome, the likelihood of recombination increases and the traits they control become less tightly linked. Linkage maps have been constructed using the proportion of recombinant gametes to determine the relative position of genes on a chromosome.

In the case of polygenic traits, such as skin color and height in humans, many different genes contribute simultaneously to the phenotype, exhibiting polygenic inheritance rather than simple linkage.

User Custadian
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