Question

The generation of sequencing technologies has come on leaps and bounds and there are stark differences between the types of technology used. There is a great Q&A here What is the difference between second and third generation sequencing?

NGS refers to high throughput massively parallel sequencing technology (See illumina's marketing page). 4th generation sequencing has been used to describe single molcule nanopore based technology (Nanopore-based Fourth-generation DNA Sequencing Technology).

So is NGS just a massively parallel version of 4th gen, or is there a more fundemental difference?

Answer 1

Next-generation sequencing (NGS) and fourth-generation sequencing (4th gen) are different technologies used for DNA sequencing. NGS is a massively parallel version of sequencing that allows for the sequencing of millions of DNA fragments simultaneously, while 4th gen sequencing uses nanopores to directly read single DNA molecules.

Step-by-step explanation:

Next-generation sequencing (NGS) and fourth-generation sequencing (4th gen) are different technologies used for DNA sequencing. NGS refers to high-throughput massively parallel sequencing technology, while 4th gen involves single molecule nanopore-based technology. NGS is a massively parallel version of sequencing that allows for the sequencing of millions of DNA fragments simultaneously, while 4th gen sequencing uses nanopores to directly read single DNA molecules.