Final answer:
Miss Havisham's life is taken by a fire that breaks out in her house, which occurs in chapter 49 of Great Expectations.
Step-by-step explanation:
In chapter 49 of Great Expectations, the physical disaster that falls upon Miss Havisham and eventually takes her life is a fire that breaks out in her house. Miss Havisham, who is dressed in her old wedding clothes, comes too close to the fire while Pip is visiting, and her dress catches ablaze. Pip heroically saves her from the flames, but she sustains severe injuries that lead to her death.