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I just watched this comedy skit that went -

Trainee: I just gave him 10 of insulin

Doctor: 10 what?

Trainee: 10cc

Doctor: * look of terror *

As a diabetic myself I know that 10cc or 1000u is an insane amount of insulin to have in one go. A 10ml vial (1000u) would usually last me over 2 weeks.

1000u in one go would most certainly be fata (if untreated) whether the patient was diabetic or not. Although individual insulin sensitivity varies greatly, I, personally, know that I would need around 1500g of sugar/glucose to counter that much insulin which I would've thought just isn't possible. What I'm wondering is, is there some other way that, assuming you're already in a hospital, they could counteract, filter out, or otherwise manage such a severe overdose? Or is IV glucose the only option?

I know glucagon injections can be use to treat severe hypoglycaemia but from my research the average person would no have enough stored glycogen. Please tell me if I'm wrong.

User Tom Dale
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1 Answer

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Final answer:

In a hospital setting, treatment for a severe insulin overdose includes IV glucose and potentially glucagon injections, but there isn't a method to directly filter out insulin. Additional interventions such as intravenous dextrose might be necessary, with continuous monitoring essential to manage the patient's condition effectively.

Step-by-step explanation:

Managing a severe insulin overdose in a hospital setting involves multiple approaches beyond intravenous (IV) glucose. While IV glucose is the mainstay for rapidly increasing blood sugar levels, in cases of significant overdose, additional treatments such as glucagon injections might be employed. Glucagon works by stimulating the liver to release stored glucose, thereby increasing blood sugar levels. However, as you correctly mentioned, the average person may have inadequate stored glycogen to fully counteract an extreme insulin overdose. In such instances, healthcare providers may also use other treatments such as intravenous dextrose infusions, which can deliver high concentrations of glucose directly into the bloodstream. Moreover, in case of renal dysfunction, the approach to managing hypoglycemia may differ as the kidney's ability to filter and reabsorb glucose changes, which must be closely monitored by medical professionals.

To address your question regarding filtering out insulin, there isn't a direct method to remove insulin from the bloodstream. The body naturally degrades and eliminates insulin, but this takes time. In a hospital, the focus is on supporting the patient's physiological functions and correcting glucose levels until the excess insulin is metabolized.

Treatment is typically personalized based on the patient's insulin sensitivity, the amount of overdose, and concurrent medical conditions. Continuous monitoring of blood glucose and vital signs is vital to guide the appropriate treatment in such critical situations.

User JJPandari
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