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Ellagic acid (a polyphenol) works as an antimicrobial compound. But what is its mechanism of action? I found these 2 research papers related to this, however the mechanism of action is not clearly explained in either of them. Is there a paper that effectively explains the mechanism of action? doi:10.3389/fmicb.2019.00829(in page 2, it is mentioned that the compounds are known to involve many sites of action at the cellular level, but why does it affect the site of action?)doi:10.1002/chem.202000354(In page 3, It has been postulated that ellagitannins inhibit the growth of microorganisms by sequestering metal ions critical for microbial growth, but direct bacterial targets remain unidentified.

Is there a paper which explains why it inhibits growth more clearly?

User BLP
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Final answer:

The detailed mechanism of action for ellagic acid's antimicrobial properties is not fully outlined in available literature, but it likely involves disrupting cell structures and sequestering metal ions similar to other phenolic compounds. Further investigation is required to specify its exact bacterial targets and mechanisms.

Step-by-step explanation:

The mechanism of action of ellagic acid as an antimicrobial compound is not fully elucidated in the literature. However, like many phenolic compounds, it may involve several modes of action. These can include disrupting microbial cell walls and membranes, precipitating proteins, and sequestering metal ions necessary for microbial growth. The exact mechanism by which ellagic acid exerts its antimicrobial effect might also vary depending on the microorganism it targets.

While specific papers explaining the detailed mechanism of ellagic acid's antimicrobial action might not be readily available, understanding the general antimicrobial action of phenolics can be helpful. Phenolics, such as triclosan and hexachlorophene, are known to disrupt cell membranes or inhibit vital processes such as fatty-acid synthesis. Since ellagic acid is a polyphenol, it's reasonable to speculate that it may act similarly by disrupting cellular structures or metabolic processes.

Further research is needed to pinpoint the exact targets and processes affected by ellagic acid in bacteria. This is a common scenario in antimicrobial research, where the activities of natural compounds can be complex and multifaceted, often requiring in-depth studies to unravel.

User Samottenhoff
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