Final answer:
The inability of current MRI technology to visualize cellular structures in vivo is due to resolution limitations. Developments in nanotechnology and nano-MRI are making progress towards cellular-level imaging, but challenges remain in achieving the necessary resolution and penetration.
Step-by-step explanation:
The significant gap in imaging technologies like MRI, which can't visualize cellular structures in vivo, stems from technological limitations. MRI is based on magnetic fields affecting atomic nuclei and is particularly adept at differentiating between tissue types due to the varied responses of hydrogen protons in different tissues. However, current MRI technology lacks the resolution to image individual cells inside the body. The spatial resolution is excellent for organ level structures but does not extend to the cellular level.
Developments in nanotechnology and nano-MRI are promising, aiming to enhance tissue contrast and identify specific biological changes at the cellular level. These advancements are leveraging nanoscale properties for tumor targeting and imaging, signifying progress towards imaging at the cellular level. However, there are still challenges in refining resolution and optimizing penetration into the body without compromising safety or image clarity.