Final answer:
High-resolution structural information can be integrated into low-resolution protein models using the Real Space Refine program in PHENIX, the Flexible Fitting plugin in VMD, and Chimera's rigid body fitting, either individually or in combination.
Step-by-step explanation:
High-resolution structural information can be combined with a lower-resolution full protein model in simulations through various methods. Real Space Refine program in PHENIX allows for the refinement of macromolecule structures based on high-resolution data. The Flexible Fitting plugin in VMD facilitates the fitting of atomic structures into density maps, which is useful when integrating high-resolution local structures into a global low-resolution model. Additionally, Chimera's rigid body fitting technique provides a way to fit high-resolution structures into low-resolution maps. All these tools can be utilized independently or in combination, depending on the requirements of the protein modeling task.
In simulations, high-resolution structural information can be imposed on a lower-resolution full protein model using various methods. One approach is to use the Real Space Refine program in PHENIX, which iteratively adjusts the low-resolution model to match the high-resolution data. Another option is to utilize the Flexible Fitting plugin in VMD, which allows for flexible adjustments of the atomic positions in the model to fit the high-resolution data. Chimera's rigid body fitting is another method that can be applied, which aligns a known high-resolution structure with multiple conformations of the low-resolution model.