Question

According to the molecular biology textbook, why are the data consistent with the hypothesis that titin's springlike behavior is due to the sequential unfolding of individual Ig domains?

A. The number of peaks in the force-versus-extension curve matches the Ig domains
B. Cross-linking of domains results in a decrease in extension
C. Spacing between peaks aligns with the sequential unfolding of Ig domains
D. Each unfolding event shows a decrease in force due to cooperativity

Answer 1

The data is consistent with the hypothesis that titin's springlike behavior is due to the sequential unfolding of individual Ig domains based on the observations of the force-versus-extension curve and cross-linking of domains.

Step-by-step explanation:

The data is consistent with the hypothesis that titin's springlike behavior is due to the sequential unfolding of individual Ig domains because of several observations. First, the number of peaks in the force-versus-extension curve matches the number of Ig domains in titin. Second, cross-linking of domains results in a decrease in extension, indicating that the unfolding of individual domains contributes to the overall spring-like behavior. Third, the spacing between peaks aligns with the sequential unfolding of Ig domains, indicating a sequential unfolding process. Lastly, each unfolding event shows a decrease in force due to cooperativity, suggesting that the unfolding of one domain facilitates the unfolding of the next.