98.8k views
4 votes
Why is the D-Galactose rat model commonly used in aging studies, and why is it not frequently used in non-human primates?

A) Non-human primates are not affected by D-Galactose

B) D-Galactose has adverse effects only in rats

C) D-Galactose is not relevant for aging studies in humans

D) The model is not suitable for primates due to metabolic differences

E) There is no information on the relevance of D-Galactose in humans

User Tcarobruce
by
9.1k points

1 Answer

2 votes

Final answer:

The D-Galactose rat model is commonly used in aging studies due to its similarity to aging processes in humans. However, it is not frequently used in non-human primates because they are less affected by D-Galactose and have different metabolic pathways.

Step-by-step explanation:

The D-Galactose rat model is commonly used in aging studies because it mimics some of the characteristics of aging, including oxidative stress, inflammation, and cognitive decline. The administration of D-Galactose to rats leads to the accumulation of advanced glycation end products (AGEs) and the generation of reactive oxygen species (ROS), which are implicated in aging processes. This model provides researchers with a way to study the molecular and cellular mechanisms underlying aging and to test potential interventions.

However, the D-Galactose rat model is not frequently used in non-human primates because non-human primates are less affected by D-Galactose compared to rats. Non-human primates have a higher activity of the enzyme galactose-1-phosphate uridylyltransferase, which helps metabolize galactose and prevent the accumulation of toxic metabolites. Therefore, the D-Galactose model is not as relevant or effective in non-human primates for studying aging processes.

User Suraj Sharma
by
8.0k points

No related questions found