Question

A scientist observes a mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding. Which hypothesis regarding the effect of this mutation on EGF signaling is most likely to be correct?

a) The mutation will intensify EGF signaling
b) The mutation will weaken EGF signaling
c) The mutation will have no effect on EGF signaling
d) The mutation will completely stop EGF signaling

Answer 1

The mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding will weaken EGF signaling.a) The mutation will intensify EGF signaling

Step-by-step explanation:

The mutation in the transmembrane region of EGFR that eliminates its ability to be stabilized by binding interactions during dimerization after ligand binding will most likely weaken EGF signaling. The dimerization of EGFR after ligand binding is a critical step in initiating the signaling cascade. Without the ability to be stabilized by binding interactions, the mutant EGFR will not be able to activate downstream signaling pathways effectively.