Final answer:
The major connection for sugars in glycolysis is the conversion of glucose-6-phosphate to fructose-6-phosphate.
Step-by-step explanation:
The major connection for sugars in glycolysis is the conversion of glucose-6-phosphate to fructose-6-phosphate. This conversion is catalyzed by the enzyme glucose-6-phosphate isomerase. It is an important step in glycolysis as it rearranges the six-carbon glucose molecule into a six-carbon fructose molecule, which can then be split into two three-carbon molecules.