Final answer:
GMOs are created through genetic engineering, which involves directly manipulating an organism's DNA using biotechnology, not through natural selection, selective breeding, or random mutation.
Step-by-step explanation:
GMOs, or Genetically Modified Organisms, are created through genetic engineering. This process involves the direct manipulation of an organism's genome using biotechnology. It is different from natural selection, which is a process occurring in nature that favors organisms better adapted to their environment, or selective breeding, where humans breed plants or animals for certain traits.
Genetic engineering to create GMOs can include techniques such as generating genomic DNA fragments with restriction endonucleases, introducing recombinant DNA into an organism, or overexpressing proteins in organisms like E. coli.
Thus, the correct answer from the options provided is b) Through genetic engineering.