Question

GTP, which can be converted to ATP, is produced during which reaction of the citric acid cycle?

a) Isocitrate to alpha-ketoglutarate
b) Succinyl-CoA to succinate
c) Citrate to isocitrate
d) Malate to oxaloacetate

Answer 1

GTP is produced during the conversion of succinyl-CoA to succinate in the citric acid cycle, which is the only step that directly forms a high-energy phosphate compound.

Step-by-step explanation:

Guanosine triphosphate (GTP), which can be converted to ATP, is produced during the reaction of succinyl-CoA to succinate in the citric acid cycle.

This is the only step in the citric acid cycle that directly forms a high-energy phosphate compound.

The enzyme succinyl-CoA synthetase catalyzes the formation of GTP from guanosine diphosphate (GDP) and inorganic phosphate, capitalizing on the energy released from the hydrolysis of the high-energy thioester bond of succinyl-CoA.

Subsequently, GTP can transfer its terminal phosphate group to adenosine diphosphate (ADP) to generate ATP through the action of nucleoside diphosphokinase.