Final answer:
Eukaryotic gene expression involves multiple regulation levels and the use of a membrane-bound nucleus, while prokaryotes primarily regulate at the transcription level. Eukaryotes have monogenic mRNAs and a more complex system due to compartmentalization.
Step-by-step explanation:
The correct statement regarding the distinction between prokaryotic and eukaryotic gene expression is that eukaryotes regulate gene expression at multiple levels including epigenetic, transcriptional, and translational, whereas prokaryotes regulate gene expression primarily at the level of transcription using repressors and activators. Unlike prokaryotes, eukaryotic cells contain a membrane-bound nucleus and show greater compartmentalization, which allows for greater regulation of gene expression. Additionally, eukaryotic mRNAs are usually monogenic, meaning that they specify a single protein. This increased complexity in eukaryotic cells leads to a requirement for protection of mRNA from degradation and the use of different polymerases for the transcription of various types of genes.