Final answer:
Eukaryotic and prokaryotic DNA differ in terms of histones, location of DNA replication, and the presence of introns.
Step-by-step explanation:
Eukaryotic and prokaryotic DNA have several similarities and differences. Firstly, with regards to the presence of histones, eukaryotic DNA is wrapped around histone proteins, which form nucleosomes. In contrast, prokaryotic DNA is not associated with histones. Secondly, in terms of the location of DNA replication, prokaryotic DNA replication occurs in the cytoplasm, while eukaryotic DNA replication occurs in the nucleus. Lastly, eukaryotic DNA contains introns, which are non-coding regions, while prokaryotic DNA does not contain introns.