Question

Which of the following will not facilitate the transfer of oxygen to tissues?

a) High partial pressure of oxygen in the lungs
b) Low partial pressure of oxygen in the tissues
c) Adequate hemoglobin levels in the blood
d) Increased cardiac output

Answer 1

Increased carbon dioxide will not facilitate the transfer of oxygen to tissues, as it reduces hemoglobin's oxygen-carrying capacity through the Bohr effect.

Step-by-step explanation:

Among the options given, increased carbon dioxide (c) will not facilitate the transfer of oxygen to tissues because it directly affects the affinity of hemoglobin for oxygen. The presence of increased carbon dioxide in the blood leads to a lowered pH level, which through the Bohr effect, reduces hemoglobin's oxygen-carrying capacity and thus its ability to release oxygen to the tissues.

This is in contrast to the Haldane effect, where a low partial pressure of oxygen promotes hemoglobin binding to carbon dioxide. Increased cardiac output, high partial pressure of oxygen in the alveoli, and low partial pressure of oxygen in the tissues enhance oxygen delivery to tissues.